BDBM416124 6-[(cis-4- methoxycyclohexyl)carbonyl]- 8-[2-(trifluoromethyl)-5,6- dihydro[1,2,4]triazolo[1,5- a]pyrazin-7(8H)-yl]-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 269

SMILES CO[C@H]1CC[C@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCn2nc(nc2C1)C(F)(F)F

InChI Key InChIKey=ZRMDSDDCRAUERD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416124   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416124(6-[(cis-4- methoxycyclohexyl)carbonyl]- 8-[2-(trif...)
Affinity DataIC50: 334nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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