BDBM416338 (8-morpholino-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- ((1- (trifluoromethyl)cyclopropyl) amino)tetrahydro-2H-pyran-2- yl]methanone::US10442819, Example 482

SMILES FC(F)(F)C1(CC1)N[C@H]1CCC(OC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1

InChI Key InChIKey=ZHDAOEDYYWTTDM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416338   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416338((8-morpholino-5,11-dihydro-6H- benzo[b]pyrido[2,3-...)
Affinity DataIC50: 506nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent