BDBM416545 US10307425, Example 11::US10632122, Example 11

SMILES COCCOc1ccc2cc(ccc2c1)-c1nn(CC2CCN(C)CC2)c2ncnc(N)c12

InChI Key InChIKey=UYNHHERHWRBIIB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 416545   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416545(US10307425, Example 11 | US10632122, Example 11)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University of Washington

US Patent
LigandPNGBDBM416545(US10307425, Example 11 | US10632122, Example 11)
Affinity DataIC50: 15.5nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416545(US10307425, Example 11 | US10632122, Example 11)
Affinity DataIC50: 15.5nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416545(US10307425, Example 11 | US10632122, Example 11)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of chicken Src using AcEIYGEFKKK as substrate after 90 mins in presence of ATP by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed