BDBM417339 US10457654, Example 199

SMILES CN([C@H]1CCCC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)C(=O)[C@H]1CCN(C)C1

InChI Key InChIKey=YERBJNYWFPYIGI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417339   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM417339(US10457654, Example 199)
Affinity DataIC50: 18.7nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM417339(US10457654, Example 199)
Affinity DataIC50: 131nMAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent