BDBM417549 6-{5-chloro-2- [(propan-2-yl)amino] pyrimidin-4-yl}-2-[2- oxo-2-(1,2,3,4- tetrahydroisoquinolin- 2-yl)ethyl]-2,3-dihydro- 1H-isoindol-1-one::US10457669, Example 164::US11001575, Example 164

SMILES CC(C)Nc1ncc(Cl)c(n1)-c1ccc2CN(CC(=O)N3CCc4ccccc4C3)C(=O)c2c1

InChI Key InChIKey=QEVUNITUMDRGCE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417549   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417549(6-{5-chloro-2- [(propan-2-yl)amino] pyrimidin-4-yl...)
Affinity DataIC50: 59nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417549(6-{5-chloro-2- [(propan-2-yl)amino] pyrimidin-4-yl...)
Affinity DataIC50: 59nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent