BDBM417962 (2R)-2-{6-[5-chloro- 2- (methylamino) pyrimidin-4-yl]-1- oxo-2,3-dihydro-1H- isoindol-2-yl}- N-[(1S)-2-hydroxy- 1-(3-methoxyphenyl) ethyl]propanamide::US10457669, Example 627::US10457669, Example 796::US11001575, Example 627

SMILES CNc1ncc(Cl)c(n1)-c1ccc2CN([C@H](C)C(=O)N[C@H](CO)c3cccc(OC)c3)C(=O)c2c1

InChI Key InChIKey=OSJDHTSLGMWJSQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 417962   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417962(US10457669, Example 627 | US10457669, Example 796 ...)
Affinity DataIC50: 5.90nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417962(US10457669, Example 627 | US10457669, Example 796 ...)
Affinity DataIC50: 5.90nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417962(US10457669, Example 627 | US10457669, Example 796 ...)
Affinity DataIC50: 31nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent