BDBM418022 (2R)-2-[6-(5-chloro-2-{[(2S)-1- hydroxypropan-2-yl]amino}pyrimidin- 4-yl)-1-oxo-2,3-dihydro-1H-isoindol-2- yl]-3-hydroxy-N-[1-(3- methylphenyl)cyclopropyl]propanamide::US10457669, Example 707::US11001575, Example 707

SMILES C[C@@H](CO)Nc1ncc(Cl)c(n1)-c1ccc2CN([C@H](CO)C(=O)NC3(CC3)c3cccc(C)c3)C(=O)c2c1

InChI Key InChIKey=KSVWUTLAGHLQIB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418022   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418022(US10457669, Example 707 | (2R)-2-[6-(5-chloro-2-{[...)
Affinity DataIC50: 10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418022(US10457669, Example 707 | (2R)-2-[6-(5-chloro-2-{[...)
Affinity DataIC50: 10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent