BDBM418526 1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-methyl-8- (1H-pyrazol-3-yl)-1,3- dihydroimidazo[4,5-c]- quinolin-2-one::US10457677, Example 121::US10975075, Example 121::US11608338, Example 121

SMILES COc1cc2ncc3n(C)c(=O)n(-c4cn(C)nc4C)c3c2cc1-c1cc[nH]n1

InChI Key InChIKey=CJVPGRMOEVWYNT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418526   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418526(1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-meth...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418526(1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-meth...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418526(1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-meth...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent