BDBM418547 8-(1-Ethyl-3-methyl-1H- pyrazol-4-yl)-1-(3-fluoro-5- methoxypyridin-4-yl)-7- methoxy-3-methyl-1,3- dihydroimidazo[4,5-c] quinolin-2-one::US10457677, Example 142::US10975075, Example 142::US11608338, Example 142

SMILES CCn1cc(c(C)n1)-c1cc2c3n(-c4c(F)cncc4OC)c(=O)n(C)c3cnc2cc1OC

InChI Key InChIKey=NIFNMZMITUDHGJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418547   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418547(8-(1-Ethyl-3-methyl-1H- pyrazol-4-yl)-1-(3-fluoro-...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418547(8-(1-Ethyl-3-methyl-1H- pyrazol-4-yl)-1-(3-fluoro-...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418547(8-(1-Ethyl-3-methyl-1H- pyrazol-4-yl)-1-(3-fluoro-...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent