BDBM419668 8-{[4-(4-fluorphenyl)piperazin-1-yl]methyl}-10-methoxy-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridin-5(6H)-one::US10464919, Example 2

SMILES COc1cc(CN2CCN(c3ccc(F)cc3)CC2)cc2[nH]c(=O)c3c(c12)NCCC3

InChI Key InChIKey=GTHQLHXXYZAOTR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 419668   

TargetPoly [ADP-ribose] polymerase 1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419668BDBM419668(US10464919, Example 2 | 8-{[4-(4-fluorphenyl)piper...)
Affinity DataIC50: 13.7nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
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Date in BDB:
9/8/2020
Entry Details
US Patent