BDBM419764 US10464919, Example 102

SMILES N#Cc1ccc(N2CC3CCC(C2)N3Cc2ccc3c4c(c(=O)[nH]c3c2)CCCN4)nc1

InChI Key InChIKey=GXXRJPKTTBCLNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419764   

TargetPoly [ADP-ribose] polymerase 1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419764BDBM419764(US10464919, Example 102)
Affinity DataIC50: 6.67nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419764BDBM419764(US10464919, Example 102)
Affinity DataIC50: 28.8nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent