BDBM419828 10-fluoro-8-{[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]methyl}-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridin-5(6H)-one::US10464919, Example 166

SMILES O=c1[nH]c2cc(CN3CCN(c4ccc([N+](=O)[O-])cc4F)CC3)cc(F)c2c2c1CCCN2

InChI Key InChIKey=VVANDCOCANQHFY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419828   

TargetPoly [ADP-ribose] polymerase 1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419828BDBM419828(US10464919, Example 166 | 10-fluoro-8-{[4-(2-fluor...)
Affinity DataIC50: 7.46nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419828BDBM419828(US10464919, Example 166 | 10-fluoro-8-{[4-(2-fluor...)
Affinity DataIC50: 36.3nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent