BDBM419838 US10464919, Example 176

SMILES N#Cc1ccc(N2CCN(Cc3cc(F)c4c5c(c(=O)[nH]c4c3)CCCN5)CC2)c(F)c1

InChI Key InChIKey=RRTBNWLSPAIIKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419838   

TargetPoly [ADP-ribose] polymerase 1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419838BDBM419838(US10464919, Example 176)
Affinity DataIC50: 11.5nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Je Il Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 419838BDBM419838(US10464919, Example 176)
Affinity DataIC50: 116nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent