BDBM421746 US10508088, Example II-17::US10538496, Compound II-17

SMILES Cc1cccc(CN2CCC3(Cc4cccc(C(=O)NO)c4C3)C2=O)c1

InChI Key InChIKey=WYGYKBCKRPZQDJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 421746   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421746(US10538496, Compound II-17 | US10508088, Example I...)
Affinity DataIC50: 750nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421746(US10538496, Compound II-17 | US10508088, Example I...)
Affinity DataIC50: 750nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent