BDBM421783 US10508088, Example II-54::US10538496, Compound II-54

SMILES CS(=O)(=O)c1ccc(CN2CCC3(Cc4cccc(C(=O)NO)c4C3)C2=O)cc1

InChI Key InChIKey=MTWDPPCOIVMDRJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 421783   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421783(US10538496, Compound II-54 | US10508088, Example I...)
Affinity DataIC50: 1.00E+3nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421783(US10538496, Compound II-54 | US10508088, Example I...)
Affinity DataIC50: 1.00E+3nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421783(US10538496, Compound II-54 | US10508088, Example I...)
Affinity DataIC50: 1.00E+3nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent