BDBM421815 US10508088, Example II-86::US10538496, Compound II-86

SMILES ONC(=O)c1cccc2CC3(CCN(Cc4ccc(c(F)c4)C(F)(F)F)C3=O)CCc12

InChI Key InChIKey=YVBQPJWWLVXEMA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 421815   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421815(US10538496, Compound II-86 | US10508088, Example I...)
Affinity DataIC50: 500nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421815(US10538496, Compound II-86 | US10508088, Example I...)
Affinity DataIC50: 500nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent