BDBM422803 US10508107, Example 9::US11312711, Example 9

SMILES Clc1cc(cnc1Cl)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1

InChI Key InChIKey=TYKADUHZARVWIN-CQSZACIVSA-N

Data  2 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 422803   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422803(US10508107, Example 9 | US11312711, Example 9)
Affinity DataKi:  480nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422803(US10508107, Example 9 | US11312711, Example 9)
Affinity DataKi:  480nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422803(US10508107, Example 9 | US11312711, Example 9)
Affinity DataIC50:  4.46E+3nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422803(US10508107, Example 9 | US11312711, Example 9)
Affinity DataEC50:  144nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR1 were amplified from genomic DNA essentially as described by Lindemann...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422803(US10508107, Example 9 | US11312711, Example 9)
Affinity DataIC50:  4.46E+3nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422803(US10508107, Example 9 | US11312711, Example 9)
Affinity DataEC50:  144nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR 1 were amplified from genomic DNA essentially as described by Lindeman...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent