BDBM426460 US10526336, Example 79::methyl 2-((2R,5R)-2-methyl-5- (pyrazolo[1,5-alpha]pyrazin-4- yloxy)piperidine-1-carbonyl)benzoate

SMILES COC(=O)c1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)Oc1nccn2ccnc12

InChI Key InChIKey=FHZTYHNAIWVNBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426460   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426460(US10526336, Example 79 | methyl 2-((2R,5R)-2-methy...)
Affinity DataIC50: 44.2nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426460(US10526336, Example 79 | methyl 2-((2R,5R)-2-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
Go to US Patent