BDBM427091 (3R)-3-(4-Chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)ethyl]-3-{[(3S,4R)-4-hydroxyoxolan-3-yl]oxy}-6-(2-hydroxypropan-2-yl)-2,3-dihydro-1H-isoindol-1-one and (3R)-3-(4-chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)ethyl]-3-{[(3R,4S)-4-hydroxyoxolan-3-yl]oxy}-6-(2-hydroxypropan-2-yl)-2,3-dihydro-1H-isoindol-1-one::US10544132, Example 46::US10981898, Example 46

SMILES C[C@H](N1C(=O)c2cc(ccc2[C@]1(OC1COC[C@@H]1O)c1ccc(Cl)cc1)C(C)(C)O)c1ccc(Cl)cc1

InChI Key InChIKey=JLJRDOGQKDSPHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427091   

LigandChemical structure of BindingDB Monomer ID 427091BDBM427091((3R)-3-(4-Chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)...)
Affinity DataIC50: 1.08E+4nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 427091BDBM427091((3R)-3-(4-Chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)...)
Affinity DataIC50: 1.08E+4nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent