BDBM427161 (3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[1-(4-fluorooxan-4-yl)-1-hydroxypropyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]propanoic Acid::US10544132, Example 101::US10981898, Example 102

SMILES CC[C@](O)(c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1)C1(F)CCOCC1

InChI Key InChIKey=HXHSKGLWTNIZIS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427161   

LigandChemical structure of BindingDB Monomer ID 427161BDBM427161((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)
Affinity DataIC50: 17nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 427161BDBM427161((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)
Affinity DataIC50: 5.50E+4nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent