BDBM429461 ALP-POS-c59291d4-2::CVD-0006351::acs.jmedchem.1c00409_ST.325::med.21724, Compound 133

SMILES CCC(=O)Nc1ccc(cc1)N(Cc2ccsc2)C(=O)Cn3c4ccccc4nn3

InChI Key InChIKey=TWIVXCFEBRGEKY-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 429461   

TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM429461(med.21724, Compound 133 | ALP-POS-c59291d4-2 | acs...)
Affinity DataIC50: 1.63E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM429461(med.21724, Compound 133 | ALP-POS-c59291d4-2 | acs...)
Affinity DataIC50: 1.63E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429461(med.21724, Compound 133 | ALP-POS-c59291d4-2 | acs...)
Affinity DataIC50: 2.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429461(med.21724, Compound 133 | ALP-POS-c59291d4-2 | acs...)
Affinity DataIC50: 2.90E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM429461(med.21724, Compound 133 | ALP-POS-c59291d4-2 | acs...)
Affinity DataIC50: 1.26E+4nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetSerine protease 1(Human)
Israel Institution of Biological Research

LigandPNGBDBM429461(med.21724, Compound 133 | ALP-POS-c59291d4-2 | acs...)
Affinity DataIC50: 9.90E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article