BDBM431185 5-[(4aR,7aR)-1-acetyl-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-4-(trifluoromethyl)-2,3-dihydropyridazin-3-one::US10550105, Example 142::US10870641, Example 142::US11014913, Example 142

SMILES CC(=O)N1CCC[C@@H]2CN(C[C@H]12)c1cn[nH]c(=O)c1C(F)(F)F

InChI Key InChIKey=FKIVGZVPKMSXDW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 431185   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431185(5-[(4aR,7aR)-1-acetyl-octahydro-1H-pyrrolo[3,4-b]p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431185(5-[(4aR,7aR)-1-acetyl-octahydro-1H-pyrrolo[3,4-b]p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431185(5-[(4aR,7aR)-1-acetyl-octahydro-1H-pyrrolo[3,4-b]p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent