BDBM431945 US10576064, Example I-17

SMILES Fc1cc2c(NC(=O)[C@]22[C@H]([C@H]3[C@H](CCNC3=O)N2CC2CC2)c2cccc(Cl)c2F)cc1Cl

InChI Key InChIKey=IVTLJFWIZFHEAJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431945   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 431945BDBM431945(US10576064, Example I-17)
Affinity DataIC50: 324nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent