BDBM432342 5-cyclopropyl-N-(1- (ethylsulfonyl)piperidin-4-yl)isoxazole-3- carboxamide::US10577363, Compound 41

SMILES CCS(=O)(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=LPPQCWHWQOZTSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 432342   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 432342BDBM432342(US10577363, Compound 41 | 5-cyclopropyl-N-(1- (eth...)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of recombinant N-terminal FLAG/His-tagged SMYD3 (unknown origin) expressed in baculovirus infected insect cells using 3H-SAM as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 432342BDBM432342(US10577363, Compound 41 | 5-cyclopropyl-N-(1- (eth...)
Affinity DataIC50: 1.39E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent