BDBM432482 N-(9-((3-aminopropyl)sulfonyl)-9- azabicyclo[3.3.1]nonan-3-yl)-5- cyclopropylisoxazole-3-carboxamide::US10577363, Compound 181

SMILES NCCCS(=O)(=O)C12CC3CC(CC(C1)N23)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=JGNXSPMZLHNSDJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 432482   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM432482(N-(9-((3-aminopropyl)sulfonyl)-9- azabicyclo[3.3.1...)
Affinity DataIC50: 92.7nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent