BDBM432811 5-cyclopropyl-N-(9-((6- (isobutyl(methyl)amino)pyridin-3- yl)sulfonyl)-9-azabicyclo[3.3.1]nonan-3- yl)isoxazole-3-carboxamide::US10577363, Compound 514

SMILES CC(C)CN(C)c1ccc(cn1)S(=O)(=O)C12CC3CC(CC(C1)N23)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=NIYVNFQLRYJBCP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 432811   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM432811(US10577363, Compound 514 | 5-cyclopropyl-N-(9-((6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent