BDBM432924 N-((3S,4R)-1-((4-(2-aminopropan-2- yl)phenyl)sulfonyl)-3-methylpiperidin-4- yl)-5-cyclopropylisoxazole-3-carboxamide::US10577363, Compound 627

SMILES C[C@H]1CN(CC[C@H]1NC(=O)c1cc(on1)C1CC1)S(=O)(=O)c1ccc(cc1)C(C)(C)N

InChI Key InChIKey=OAKNDOZPJKWSLB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 432924   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM432924(US10577363, Compound 627 | N-((3S,4R)-1-((4-(2-ami...)
Affinity DataIC50: 26.5nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent