BDBM434872 7-[(11S,14R)-16-Oxa-3,4,10-triazatetracyclo[15.3.1.13,6.111,14]tricosa-1(21),4,6::US10577383, Example 32

SMILES Nc1cc(C2CCN[C@H]3CC[C@H](C3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1

InChI Key InChIKey=BNWPDLXDVHATOM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 434872   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434872(US10577383, Example 32 | 7-[(11S,14R)-16-Oxa-3,4,1...)
Affinity DataIC50: 50nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434872(US10577383, Example 32 | 7-[(11S,14R)-16-Oxa-3,4,1...)
Affinity DataIC50: 550nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent