BDBM435293 US10568876, Example 56::methyl 3-(2-((3,3-difluorocyclobutyl) carbamoyl)-8-((2- phenylcyclopropanecarboxamido)methyl)- 1,2,3,4-tetrahydroisoquinolin-5-yl) benzoate (mixture of 4 isomers)

SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)NC1CC(F)(F)C1

InChI Key InChIKey=ATWLKADAAFLDGW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435293   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435293(US10568876, Example 56 | methyl 3-(2-((3,3-difluor...)
Affinity DataIC50: 9.88nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent