BDBM437360 5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-1- methylpyridin-2(1H)-one::US10617680, Example 94::US11020380, Example 94

SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-n1ccnc1

InChI Key InChIKey=RSJRTVTWDZJJHY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 437360   

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437360BDBM437360(5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437360BDBM437360(5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437360BDBM437360(5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437360BDBM437360(5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BRD4 was determined as described previously. See, e.g., U.S. Pat. No. 9,034,900.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437360BDBM437360(5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent