BDBM437589 2-(4-(4-(2-(ethylamino)pyrimidin-5-yl)-1-methyl-6-oxo- 1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile::US10617680, Example 323::US11020380, Example 323
SMILES CCNc1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
InChI Key InChIKey=LRGADKFKDSBTAM-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 437589
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of BRD4 was determined as described previously. See, e.g., U.S. Pat. No. 9,034,900.More data for this Ligand-Target Pair
Affinity DataIC50: 2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair