BDBM438540 N-(3-cyano-3-methylbutyl)-6-(6-cyanopyrazolo[1,5-a]pyrimidin-3-yl)-4-(isopropylamino)nicotinamide::US10618903, Example 169

SMILES CC(C)Nc1cc(ncc1C(=O)NCCC(C)(C)C#N)-c1cnn2cc(cnc12)C#N

InChI Key InChIKey=JBECFAPYDURGTG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 438540   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM438540(N-(3-cyano-3-methylbutyl)-6-(6-cyanopyrazolo[1,5-a...)
Affinity DataIC50: 8nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent