BDBM440554 US10633389, Example 220-3::US20230279020, Example 220-3

SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N(C)C2CC(COC)C2)c(C)c(n1)-c1c(C)noc1C

InChI Key InChIKey=JTOXYVZJHPWSPX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 440554   

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM440554(US10633389, Example 220-3 | US20230279020, Example...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM440554(US10633389, Example 220-3 | US20230279020, Example...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent