BDBM445668 Ex. 6/KM-06-80/(I-6)::US10683309, Example 6::US11028104, Example 6

SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)C(O)=O)c2c(=O)[nH]c1=O

InChI Key InChIKey=ZRFNOGXIUVPGGT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 445668   

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM445668(Ex. 6/KM-06-80/(I-6) | US10683309, Example 6 | US1...)
Affinity DataIC50: 272nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM445668(Ex. 6/KM-06-80/(I-6) | US10683309, Example 6 | US1...)
Affinity DataIC50: 272nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM445668(Ex. 6/KM-06-80/(I-6) | US10683309, Example 6 | US1...)
Affinity DataIC50: 272nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445668(Ex. 6/KM-06-80/(I-6) | US10683309, Example 6 | US1...)
Affinity DataIC50: 7.83E+3nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445668(Ex. 6/KM-06-80/(I-6) | US10683309, Example 6 | US1...)
Affinity DataIC50: 7.83E+3nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent