BDBM445963 US10669246, Example 15::US10968188, Example 15

SMILES Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1)C(C)(C)O

InChI Key InChIKey=HOBZHRIFYVYKHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445963   

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445963(US10669246, Example 15 | US10968188, Example 15)
Affinity DataIC50: 116nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445963(US10669246, Example 15 | US10968188, Example 15)
Affinity DataIC50: 116nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent