BDBM447572 1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxalin-2-yl)piperidin-4-yl acetate::US10689362, Example 68

SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCC(CC3)OC(C)=O)cc2OC)cc1

InChI Key InChIKey=OLYXPYMVMOJOIU-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 447572   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447572(1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)p...)
Affinity DataKi:  27.5nMAssay Description:c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447572(1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)p...)
Affinity DataIC50: >1.00E+6nMAssay Description:PDGFRβ: Inhibition of PDGFRβ kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447572(1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)p...)
Affinity DataIC50: >1.00E+6nMAssay Description:FLT3: Inhibition of FLT3 kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 5 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447572(1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)p...)
Affinity DataIC50:  27.5nMAssay Description:CSF-1R: Inhibition of CSF-1R kinase activity by a test compound disclosed herein was estimated by AlphaScreen (PerkinElmer). Standard assay condition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent