BDBM447660 (3aR,6aR)-5-cyano-N-(4- cyano-2,5-difluorophenyl) hexahydropyrrolo[3,4-b] pyrrole-1(2H)-carboxamide::US10689345, Example 199::US11066365, Example 199::US11390584, Example 199

SMILES Fc1cc(C#N)c(F)cc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N

InChI Key InChIKey=XFIIBVSNYNKNHD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 447660   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM447660((3aR,6aR)-5-cyano-N-(4- cyano-2,5-difluorophenyl) ...)
Affinity DataIC50: 550nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM447660((3aR,6aR)-5-cyano-N-(4- cyano-2,5-difluorophenyl) ...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM447660((3aR,6aR)-5-cyano-N-(4- cyano-2,5-difluorophenyl) ...)
Affinity DataIC50: 550nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
Go to US Patent