BDBM448703 US10695337, Example 269::{1-{1-[2-fluoro-5- (trifluoromethoxy)benzoyl]piperidin- 4-yl}-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrrol-1-yl]azatidin-3-yl}acetamide

SMILES NC(=O)CC1(CN(C1)C1CCN(CC1)C(=O)c1cc(OC(F)(F)F)ccc1F)n1ccc(c1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=KNDWTTBHBYGPBU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448703   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandPNGBDBM448703(US10695337, Example 269 | {1-{1-[2-fluoro-5- (trif...)
Affinity DataIC50: 5nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte Holdings

US Patent
LigandPNGBDBM448703(US10695337, Example 269 | {1-{1-[2-fluoro-5- (trif...)
Affinity DataIC50: 30nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent