BDBM450524 N-[(4-Chloro-3-cyanophenyl)methyl]-N-methyl-2-[4-oxo-6-[4-(oxolan-3-ylmethyl)piperazin-1-yl]quinazolin-3-yl]acetamide::US10676446, Example 115

SMILES CN(Cc1ccc(Cl)c(c1)C#N)C(=O)Cn1cnc2ccc(cc2c1=O)N1CCN(CC2CCOC2)CC1

InChI Key InChIKey=UCNATGYANLLVMG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450524   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 450524BDBM450524(US10676446, Example 115 | N-[(4-Chloro-3-cyanophen...)
Affinity DataIC50: 29nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent