BDBM450871 5-(((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-N-methyl-8-(2-methylpyridin-3-yl)imidazo[1,5-c]pyrimidine-1-carboxamide::US10676479, Example 2

SMILES CNC(=O)c1ncn2c(NCc3c4CCOc4ccc3F)ncc(-c3cccnc3C)c12

InChI Key InChIKey=GTPFFCKGIGDQSR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450871   

LigandChemical structure of BindingDB Monomer ID 450871BDBM450871(US10676479, Example 2 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 12.3nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450871BDBM450871(US10676479, Example 2 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 12.6nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 450871BDBM450871(US10676479, Example 2 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 26.7nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent