BDBM450971 (8-(2,4-Dimethylpyrimidin-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,5-c]pyrimidin-1-yl)methanol::US10676479, Example 8

SMILES Cc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(CO)c12

InChI Key InChIKey=AKZXZQQRQDPNDI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450971   

LigandPNGBDBM450971(US10676479, Example 8 | (8-(2,4-Dimethylpyrimidin-...)
Affinity DataIC50: 11.6nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM450971(US10676479, Example 8 | (8-(2,4-Dimethylpyrimidin-...)
Affinity DataIC50: 18.6nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM450971(US10676479, Example 8 | (8-(2,4-Dimethylpyrimidin-...)
Affinity DataIC50: 30.4nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent