BDBM451036 N-(benzofuran-4-ylmethyl)-8-(6-(piperazin-1-::US10676479, Example 66

SMILES C(Nc1ncc(-c2ccc(nc2)N2CCNCC2)c2cncn12)c1cccc2occc12

InChI Key InChIKey=IVOFNUACKQVXGT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451036   

LigandChemical structure of BindingDB Monomer ID 451036BDBM451036(US10676479, Example 66 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 49.3nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451036BDBM451036(US10676479, Example 66 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 72.1nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451036BDBM451036(US10676479, Example 66 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 444nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent