BDBM451043 8-(2-(difluoromethyl)pyridin-3-yl)-5-(((5-fluoro-::US10676479, Example 73

SMILES FC(F)c1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(C#N)c12

InChI Key InChIKey=LFTRNDNTKBGXCT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451043   

LigandChemical structure of BindingDB Monomer ID 451043BDBM451043(US10676479, Example 73 | 8-(2-(difluoromethyl)pyri...)
Affinity DataIC50: 23.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451043BDBM451043(US10676479, Example 73 | 8-(2-(difluoromethyl)pyri...)
Affinity DataIC50: 55.3nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451043BDBM451043(US10676479, Example 73 | 8-(2-(difluoromethyl)pyri...)
Affinity DataIC50: 56.4nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent