BDBM451060 5-((2-fluoro-6-methoxybenzyl)amino)-8-(2-::US10676479, Example 90

SMILES COc1cccc(F)c1CNc1ncc(-c2cccnc2C)c2c(ncn12)C#N

InChI Key InChIKey=XRTLMSCRDZOHHB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451060   

LigandChemical structure of BindingDB Monomer ID 451060BDBM451060(US10676479, Example 90 | 5-((2-fluoro-6-methoxyben...)
Affinity DataIC50: 56.8nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451060BDBM451060(US10676479, Example 90 | 5-((2-fluoro-6-methoxyben...)
Affinity DataIC50: 139nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451060BDBM451060(US10676479, Example 90 | 5-((2-fluoro-6-methoxyben...)
Affinity DataIC50: 337nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent