BDBM451061 US10676479, Example 91::ethyl 8-bromo-5-(((5-fluoro-2,3-

SMILES CCOC(=O)c1ncn2c(NCc3c4CCOc4ccc3F)ncc(Br)c12

InChI Key InChIKey=PSDUHHKPZROJCO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451061   

LigandChemical structure of BindingDB Monomer ID 451061BDBM451061(US10676479, Example 91 | ethyl 8-bromo-5-(((5-fluo...)
Affinity DataIC50: 8nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451061BDBM451061(US10676479, Example 91 | ethyl 8-bromo-5-(((5-fluo...)
Affinity DataIC50: 8.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 451061BDBM451061(US10676479, Example 91 | ethyl 8-bromo-5-(((5-fluo...)
Affinity DataIC50: 32nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent