BDBM451084 8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-::US10676479, Example 114

SMILES Cc1ccc(cn1)-c1ncn2c(NCc3c4CCOc4ccc3F)ncc(-c3cnc(C)nc3C)c12

InChI Key InChIKey=UATGKUUUDPUKBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451084   

LigandPNGBDBM451084(US10676479, Example 114 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 8.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451084(US10676479, Example 114 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 22.8nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM451084(US10676479, Example 114 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 31.9nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent