BDBM454387 US10717742, Example Ia-47::US10882866, Example Ia-47

SMILES Fc1c(Cl)cccc1[C@H]1[C@H]2[C@H](Cc3n2nc2cc(ccc32)C(=O)NC2CC2)N(CC2CCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=ZCULFHDDGIIOCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454387   

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 454387BDBM454387(US10717742, Example Ia-47 | US10882866, Example Ia...)
Affinity DataIC50: 9nMAssay Description:15 μL of compound in 20% DMSO (serial pre-dilutions of compound are done in 100% DMSO) is pipetted to the wells of a white OptiPlate-96 (Perkin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 454387BDBM454387(US10717742, Example Ia-47 | US10882866, Example Ia...)
Affinity DataIC50: 9nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent