BDBM454413 US10717742, Example Ib-121::US10882866, Example Ib-121

SMILES CC(C)=CCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12

InChI Key InChIKey=XJHOKPKOVATLAF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454413   

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 454413BDBM454413(US10717742, Example Ib-121 | US10882866, Example I...)
Affinity DataIC50: 11nMAssay Description:15 μL of compound in 20% DMSO (serial pre-dilutions of compound are done in 100% DMSO) is pipetted to the wells of a white OptiPlate-96 (Perkin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 454413BDBM454413(US10717742, Example Ib-121 | US10882866, Example I...)
Affinity DataIC50: 11nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent