BDBM454852 US10730870, Example 15::US11512083, Example 15

SMILES COc1cccc2CN([C@@H](C(C)C)C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(=O)c12

InChI Key InChIKey=OOJPKSNELSHOJZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 454852   

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454852(US10730870, Example 15 | US11512083, Example 15)
Affinity DataIC50: 1.22E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454852(US10730870, Example 15 | US11512083, Example 15)
Affinity DataIC50: 1.22E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454852(US10730870, Example 15 | US11512083, Example 15)
Affinity DataIC50: 2.45E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454852(US10730870, Example 15 | US11512083, Example 15)
Affinity DataIC50: 2.45E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454852(US10730870, Example 15 | US11512083, Example 15)
Affinity DataIC50: 8.19E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454852(US10730870, Example 15 | US11512083, Example 15)
Affinity DataIC50: 8.19E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent