BDBM454923 US10730870, Example 90::US11512083, Example 90

SMILES CC(=O)NC(C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(F)(F)F

InChI Key InChIKey=QFIBPTJZUZOBKU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454923   

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454923BDBM454923(US10730870, Example 90 | US11512083, Example 90)
Affinity DataIC50: 4.52E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454923BDBM454923(US10730870, Example 90 | US11512083, Example 90)
Affinity DataIC50: 4.52E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454923BDBM454923(US10730870, Example 90 | US11512083, Example 90)
Affinity DataIC50: 4.79E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454923BDBM454923(US10730870, Example 90 | US11512083, Example 90)
Affinity DataIC50: 4.79E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent